Microsoft recently published an official .NET team blog post reiterating that .NET Framework versions 4, 4.5, and 4.5.1 will no longer receive security updates, support, or hotfixes as of January 12, 2016. This was first announced back in August of 2014, so it’s not like this is new news, but I can say from experience virtually no one is talking about it. MS’ new post talks more about the upgrade path. To sum it up, you need to install .NET Framework 4.5.2, 4.6, or 4.6.1 to be considered supported when it comes to your .NET Framework version. Security is a real issue for many, and those responsible may not know that your version of .NET Framework could be a possible attack vector. Is your security team aware of this impending problem? How will this affect your version matrices (you do have those, right?)?
This is a cross-cutting concern, and I know a majority of database administrators aren’t directly responsible for .Net Framework patches, but work with whoever is responsible and keep them up to date.