I recently had a project in which I needed to transfer a 60 GB SQLite database to SQL Server. After some research I found the sqlite3 and pyodbc modules, and set about scripting connections and insert statements.
The basic form of my script is to import the modules, setup the database connections, and iterate (via cursor) over the rows of the select statement creating insert statements and executing them.
The issue here is that this method results in single inserts being sent one at a time yielding less than satisfactory performance. Inserting 35m+ rows in this fashion takes ~5hrs on my system.
Jon tries out a few different options. It would appear that there is no easy bulk insertion operation with PyODBC.