Ginger Keys has an analysis stress testing CPU load when Transparent Data Encryption is on and a database is in an Availability Group:
Microsoft says that turning on TDE (Transparent Data Encryption) for a database will result in a 2-4% performance penalty, which is actually not too bad given the benefits of having your data more secure. There is even more of a performance hit when enabling cell level or column level encryption. When encrypting any of your databases, keep in mind that the tempdb database will also be encrypted. This could have a performance impact on your other non-encrypted databases on the same instance.
In a previous post I demonstrated how to add an encrypted database to an AlwaysOn group in SQL2016. In this article I will demonstrate the performance effects of having an encrypted database in your AlwaysOn Group compared to the same database not-encrypted.
The results aren’t surprising, though the magnitude of the results might be.