I was working with a client recently, were we had to reconfigure storage within a VM (which is always a messy proposition). In doing so, we were adding and removing disks from the VM. this all happened mostly during a downtime window, so it wasn’t a big deal to down a VM, which is how you can remove a disk from a VM via the portal. However, upon further research, I learned that through the portal you can remove a disk from a running VM.
Read on to see how. Though I’d generally still recommend shutting the VM off first just to be sure.