Matthew McGiffen shares some tips on running SQL Server in Amazon RDS:
Or you can go with Amazon RDS (Relational Database Service). This is more of a managed service where Amazon looks after some aspects of your database server for you. In return you give up some of the control you would have with your own server or VM. You can still pick the version of SQL Server you want installed, usually down to which cumulative update you want – though note that RDS normally lags behind the latest box version of SQL by 3 months or so. RDS is what’s known as a PaaS offering (Platform as a Service).
So, what do you give up and what do you gain? Here’s a quick summary of a few things I’ve noticed. This is not intended to be comprehensive and please bear in mind that AWS is a fast-moving beast – changes happen regularly.
There are some good tips here, so check them out.