There are lots of ways to manage noisy neighbors. For example, you could spin up additional instances of SQL Server on a single physical or virtual machine (VM), and then segregate the applications to a distinct instance. You could also follow the old adage of “one application, one SQL Server” by putting the SQL Server onto its own machine, either physical or virtual. But that can get very expensive very quickly, depending on your licensing methodology.
If you’re running SQL Server 2008 or later, you might want to investigate Resource Governor as an alternative. Resource Governor lets you create limits on the amount of system resources a database and application can consume. On versions 2008 to 2012, Resource Governor can explicitly limit CPU and memory and, starting with version 2014, limit I/O consumption as well. This is powerful medicine for multi-tenant instances with noisy neighbors!
My response to noisy neighbors is to turn my music up really loud as a passive-aggressive response. Oh, wait, wrong kind of noisy neighbor… H/T SentryOne