Josephine Bush doesn’t need enormous system databases:
Always set this on your SQL Servers so you don’t have this problem in the first place. This is in the SQL Server Agent settings. I remember having some agent jobs that used to serve this function that ran on a schedule, which may have been required in older versions of SQL Server.
Josephine focuses on SQL Agent history and database backup history, both of which are good ones. If you have an older version of SQL Server or are using the package deployment model, there may be an explosion of information in msdb regarding SSIS that you’d want to manage. Also, check if any of the databases are in Full recovery mode; if so, ensure that the backup script you’re using for transaction log backups actually backs up system databases.