Fun with Multi-Column Unique Constraints

Aaron Bertrand has an interesting use case:

A problem that comes up occasionally with constraints in SQL Server is when a unique constraint applies to multiple columns, but the values in those columns can be populated in any order. For example, if a table holds interactions between two users, and has columns User1 and User2, there should only be one row allowed for users 100 and 200, regardless of whether the data is entered as 100, 200 or 200, 100.

Click through for one solution. Another solution would be to normalize this down further with a dbo.ConversationParticipants table.