One thing I’ve found is that the inflated counts don’t seem to change anything for Identities, or Primary Keys. You’ll always get very reasonable plans and estimates regardless of how high you set row and page counts for those. Regular old clustered indexes are fair game.
Some really interesting things can start to happen to execution plans when SQL thinks there’s this many rows in a table. The first is that SQL will use a rare (in my experience) plan choice: Index Intersection. You can think of this like a Key Lookup but with two nonclustered indexes rather than from one nonclustered index to the clustered index.
This is very useful when you don’t have many rows in dev, can’t put many rows in dev, and can’t restore a stats-only database from prod.