AMD is really pushing the idea of a single-socket EPYC system as a better alternative to a two-socket Intel system for many server workloads. According to AMD, it will be much less expensive, yet will have plenty of cores, memory, and PCIe 3.0 lanes, along with no NUMA overhead. One key advantage AMD is touting is their Infinity Fabric modular interconnect technology, that works both within a single processor and between multiple processors.
For SQL Server 2016/2017 usage, you would still want the “top of the line” SKU for a given physical core count, to get the most performance for each physical core license that you buy. Unlike Intel, AMD does not increase the base clock speed in the lower core count models. These EPYC systems have a lot of PCIe 3.0 lanes and very high memory density, so they might work really well for large SQL Server DW/Reporting workloads. For OLTP workloads, the key will be how much single-threaded performance AMD is able to get from this first-generation of EPYC, and how they compare to Intel’s new Skylake-SP processors. Figure 3 shows the fastest EPYC processor at each core count, which is what you would want for SQL Server usage.
There aren’t too many hard numbers yet, but the worst case scenario is that they force Intel to improve their offerings.